Point Marion is located at the confluence of the Monongahela and Cheat Rivers. Approximately three miles north of Point Marion is Friendship Hill National Historic Site, home of early American politician Albert Gallatin. Point Marion was settled in the mid-18th century and named in 1842 for its geographic location and Revolutionary War hero Francis Marion, the "Swamp Fox", a South Carolinian who never saw the town.
Houze Glass Co., located in the borough, was the primary employer. The company was founded by Leon Houze, a Belgian immigrant, in 1902 as a glassware manufacturer, but later branched into silkscreen printing and decorating. The company closed in 2004 and the plant later auctioned off.